Table 2:

Up and downregulated upstream regulators with z-score ≥2 in mPIA and sPIA animals

Upregulated Genes						Downregulated Genes
sPIA Males			sPIA Females			sPIA Males			sPIA Females
Upstream Regulator	Activation z-score	Genes affected	Upstream Regulator	Activation z-score	Genes affected	Upstream Regulator	Activation z-score	Genes affected	Upstream Regulator	Activation z-score	Genes affected
HOXA10	2.11	11	IRF7	3.741	19	CREB1	−3.385	37	CREB1	−3.819	93
NEUROG1	2.0	4	EPAS1	3.227	32	CEBPB	−3.347	28	TRIM24	−3.208	17
			IRF3	3.212	20	ESR1	−3.181	84	SOX1	−3.162	10
			ESR1	3.123	117	HTT	−3.046	47	SOX3	−3.162	10
			STAT1	3.093	44	SIX5	−2.828	8	GMNN	−2.525	11
			STAT4	2.984	32	ID1	−2.777	8	NKX2–1	−2.43	21
			SPI1	2.63	24	CREBBP	−2.578	34	RUNX3	−2.389	13
			EGR2	2.598	20	SRF	−2.57	23	RUNX1	−2.384	17
			PARP1	2.409	16	LHX1	−2.496	13	IRF4	−2.359	14
			NFATC2	2.403	22	CEBPA	−2.441	29	TFAP2A	−2.348	8
			IRF1	2.384	17	JUNB	−2.401	7	NEUROG1	−2.309	12
			HMGB1	2.379	7	FOXO3	−2.347	18	NUPR1	−2.271	38
			KLF4	2.273	36	CEBPE	−2.335	8	SS18	−2.236	6
			HDAC9	2.236	5	THRA	−2.232	10	HOXA10	−2.231	19
			REL	2.22	28	PLAG1	−2.177	8	HHEX	−2.211	8
			NFAT5	2.219	8	HNF4A	−2.11	80	KLF5	−2.2	5
			NFKBIB	2.157	12	MRTFA	−2.045	11	NR3C1	−2.109	62
			HNF1B	2.137	11	NR3C2	−2.03	10
			KDM5A	2.132	9	SATB1	−2.025	11
			CTNNB1	2.068	84	SIM1	−2	21
			IRF5	2.038	11
			RSF1	2	4
			TGFB1I1	2	4