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Schematic representation of the main findings of this study. It is demonstrated that osteoclasts inhibit osteoblast differentiation of cells grown on both Ti Control and Ti Nano and that Ti Nano attenuates the osteoclast-induced disruption of osteoblast differentiation by preventing the accumulation of H3K27me3 in the promoter regions of Runx2 and Alpl. The reader is referred to the web version of this article for the colour representation of this figure.
