. 2022 Apr 16;8(2):181–194. doi: 10.1007/s41030-022-00187-8

Table 2.

Univariate and multivariate associations, with multiple imputation, of QoL metrics at baseline with mortality (N = 277)

QoL measure	Univariate analyses^a			Multivariate analyses^a,b
QoL measure	HR^c	95% CI	p value	HR^b	95% CI	p value
Cough VAS	1.02	(0.97–1.07)	0.3999	1.01	(0.96–1.07)	0.7586
EQ-5D VAS score	0.90	(0.83–0.99)	0.0031	0.96	(0.88–1.05)	0.3764
SGRQ total score	1.14	(1.05–1.23)	0.0003	1.12	(1.04–1.21)	0.0042
SGRQ impact score	1.10	(1.03–1.17)	0.0013	1.09	(1.03–1.17)	0.0115
SGRQ activity score	1.08	(1.02–1.15)	0.0083	1.06	(0.99–1.12)	0.0675
SGRQ symptoms score	1.11	(1.04–1.19)	0.0003	1.10	(1.03–1.17)	0.0037

CI, confidence interval; DLco, diffusing capacity of the lungs for carbon monoxide; EQ-5D, EuroQoL-5 dimensions Health Questionnaire; FVC, forced vital capacity; HR, hazard ratio; QoL, quality of life; SGRQ, St. George’s Respiratory Questionnaire; VAS, visual analogue scale

^aData were considered missing at random and multiple imputations were performed

^bMultivariate analyses adjusted for age, sex, percent predicted FVC, percent predicted DLco, smoking status and supplementary oxygen use at baseline

^cHR for every five-point increase in scores