Table 3. Outcomes of antibiotic prophylaxis as per included studies.

CRI - Catheter-Related Infections

CVAP - Central Venous Access Ports

Reference	Design	Cases	Conclusion
Evan Johnson et al. (2016) [55]	Meta-analysis	2154	No significant difference in infection rates.
Anne M. Covey et al. (2012) [56]	Retrospective chart review	1183	The infection rate without antibiotic prophylaxis is < 1%.
Courtney L Scaife et al. (2010) [57]	Retrospective review	459	All 9 (2%) CRIs occurred in the non-prophylactic antibiotic group (P = .218), with 5 infections resulting in port removal. Single-dose perioperative antibiotics may decrease CVAP infection rates and should be studied further in a prospective randomized trial.