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. 2022 Apr 18;11(2):667–681. doi: 10.1007/s40122-022-00386-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 1 — Effect of oxycodone on inflammatory cytokines in patients with moderate to severe cancer pain. A–F: IL-2 (A), IL-4 (B), IL-6 (C), IL-10 (D), TNF-α (E), and IFN-γ (F) levels in the two groups of cancer patients. Control: the control group (n = 100). Opioid: the opioid group (n = 86). Data are expressed as the mean ± SD. *p < 0.05, **p < 0.01, and ***p < 0.001 vs. the control group