Figure 3.

The potential mechanism of IR injury and NAFLD caused by ROS. ROS leads to the inactivation of antioxidants, which reduce the scavenging of ROS, and the imbalance of the ROS and antioxidant results in oxidative stress. Oxidative stress promotes inflammation, mitochondrial damage as well as cell death, leading to hepatic ischemia-reperfusion injury and NAFLD (black arrows). The presence of NAFLD resulted in excessive ROS generation during IR, weaker antioxidant capacity, aggravated oxidative stress and enhanced IR injury (red arrows).