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. 2022 Apr 29;9:879355. doi: 10.3389/fcvm.2022.879355

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Copyright © 2022 Xiao, Luo and Peng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of LDL-C lowering drugs or genetic variants on glucose metabolism. LDL-C lowering drugs or genetic variants disturb glucose homeostasis via multiple ways. Genetic PCSK9 deficiency impairs pancreatic β-cell insulin secretion while NPC1L1 inhibitors and genetic NPC1L1 deficiency lead to insulin resistance of hepatocyte. HMGCR inhibitors and genetic HMGCR deficiency impairs pancreatic β-cell insulin secretion and induce insulin resistance of skeletal muscle cell, adipocyte, and hepatocyte.