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. 2022 Apr 29;13:867600. doi: 10.3389/fendo.2022.867600

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Copyright © 2022 Wang, Wei, Liu, Zhang, Xia, Ding and Xiong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The idea of experimental design. The gene expression profiles of LCLs extracted from the peripheral blood of 7 non-diabetic individuals and 8 patients with DR were cultured under SG and HG conditions respectively in the GSE146615 dataset. 232 autophagy-related genes were collected from The Human Autophagy Database. Then, 9 up-regulated genes and 14 down-regulated genes were screened by differential analysis. After enrichment analysis and PPI network construction, 10 hub genes were identified. Finally, qRT-PCR was used to verify in vitro DR model. LCLs, lymphoblastoid cell lines; DR, diabetic retinopathy; SG, standard glucose; HG, high glucose; PPI, protein-protein interaction; qRT-PCR, quantitative real-time polymerase chain reaction.