Table 3.
Functional and pathway enrichment analyses for module genes.
| Term | Description | Count | P-value | Adj. P-value | Genes |
|---|---|---|---|---|---|
| Biological processes | |||||
| GO:0010506 | Regulation of autophagy | 10 | 2.07E-12 | 2.88E-09 | TSC1, ITPR1, CAMKK2, NPC1, DRAM1, CHMP4B, MAPK3, BAG3, FOXO3, DAPK1 |
| GO:0010508 | Positive regulation of autophagy | 6 | 5.40E-09 | 3.76E-06 | TSC1, CAMKK2, MAPK3, BAG3, FOXO3, DAPK1 |
| GO:0009896 | Positive regulation of catabolic process | 8 | 3.53E-08 | 1.64E-05 | |
| Cellular component | |||||
| GO:0005770 | Late endosome | 6 | 6.11E-07 | 7.78E-05 | HGS, NPC1, CHMP4B, MAPK3, MAPK1, CXCR4 |
| GO:0005741 | Mitochondrial outer membrane | 5 | 2.75E-06 | 1.24E-04 | BAX, RAF1, BID, BCL2L1, FOXO3 |
| GO:0031968 | Organelle outer membrane | 5 | 4.96E-06 | 1.40E-04 | |
| Molecular functions | |||||
| GO:0051087 | Chaperone binding | 4 | 7.08E-06 | 9.56E-04 | BAX, TSC1, CDKN1B, BAG3 |
| GO:0044389 | Ubiquitin-like protein ligase binding | 5 | 3.61E-05 | 2.44E-03 | HGS, RB1, GABARAPL2, BID, CXCR4 |
| GO:0004674 | Protein serine/threonine kinase activity | 5 | 1.64E-04 | 3.29E-03 | RAF1, CAMKK2, MAPK3, MAPK1, DAPK1 |
| KEGG pathway | |||||
| hsa04140 | Autophagy – animal | 6 | 2.11E-08 | 3.12E-06 | GABARAPL2, RAB33B, MAPK3, BCL2L1, MAPK1, DAPK1 |
| hsa04068 | FoxO signaling pathway | 5 | 7.37E-07 | 5.46E-05 | CDKN1B, GABARAPL2, MAPK3, MAPK1, FOXO3 |
| hsa05163 | Human cytomegalovirus infection | 5 | 8.23E-07 | 1.12E-04 | BAX, RAF1, TSC1, ITPR1, RB1 |
The top 3 terms were selected based upon Adj. P-value rankings when>3 terms were enriched for a given category.