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. 2022 May 12;5:449. doi: 10.1038/s42003-022-03376-y

Fig. 3. Macrophages mediate the protective effect of β-glucan in MIP.

Fig. 3

Arthritis severity was followed in MIP induced in Ncf1-deficient (a), Ncf1 and MMR-deficient (b) or MMR-deficient (c) mice with or without co-administration of 1,3–1,6-β-glucan (5 mg; a, b) or 1,6-β-glucan (2 mg; c). After 18 days, MIP was re-induced by the administration of mannan to investigate the long-term effects of β-glucans. MIP was induced in MN + and Ncf1-deficient mice (d) with or without co-administration of 1,6-β-glucan (2 mg) to investigate the effect of Ncf1 expressed under the human CD68 promoter on the Ncf1-deficient background in MN + mice. The data are from three combined experiments in (a, b, d), and from one experiment in (c, d). Number of mice in each group is shown in parentheses in the legend. Statistical analyses were performed by Mann–Whitney test to compare the group receiving mannan with the group receiving mannan and β-glucan. *P < 0.05; **P < 0.01; and ***P < 0.001. Results are presented as mean and error bars represent the SEM.