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. 2022 Apr 29;9:876795. doi: 10.3389/fcvm.2022.876795

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Copyright © 2022 Carvalho, Nogueira, Bonilha, Luchiari, Benchimol, Couri, Borges, Barreto and Sposito.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Study network. The study network presents sharp connections between placebo vs. GLP1-RA, placebo vs. SGLT2i, placebo vs. DPP4i and placebo vs. TZD (pioglitazone). The nodes for Sulfonylurea, TZD, DPP4i, GLP1-RA, SGLT2i are also tightly connected with most treatment arms, however, it is possible to observe a poor connection between drug combinations (SGLT2i+GLP1-RA, GLP1-RA1+Insulin, SGLT2i+DPP4i, GLP1-RA+TZD, etc) and other treatment arms. By using additive component network meta-analysis, it is possible to account for both single treatments and combinations, but the combinations may be more prone to depend on the effect of indirect comparisons if paralleled to single treatment comparisons.