Table 3.

Sensitivity analyses^¥ using meta-regression models for the hazard ratio of MACE as dependent variable.

	HR	95% CI		p
		Lower bound	Upper bound
Bivariate analyses
Achieved HbA1c at study end in the active arm (HbA1c ≤ 7.0% vs. HbA1c > 7.0%) vs. MACE
All trials‡ (132 study arms)	0.9560	0.7703	1.1865	0.680
SGLT2i, DPP4i, Pioglitazone or GLP1-RA in the active arm (62 study arms*)	0.8033	0.6338	0.9773	0.031
Change in HbA1c in the active arm compared to control (each reduction of 1%) vs MACE
All trialsø (132 study arms)	0.9036	0.7300	1.0526	0.215
SGLT2i, DPP4i, Pioglitazone or GLP1-RA in the active arm◇ (62 study arms*)	0.8265	0.6769	0.9581	0.009
Multivariate analyses**
		Lower bound	Upper bound
Achieved HbA1c at study end in the active arm (HbA1c ≤ 7.0% vs. HbA1c > 7.0%) vs. MACE
All trials‡‡ (109 study arms§)	0.8598	0.7082	1.0439	0.073
SGLT2i, DPP4i, Pioglitazone or GLP1-RA in the active arm (49 study arms*§)	0.8328	0.7168	0.8755	0.004
Change in HbA1c in the active arm compared to control (each reduction of 1%) vs MACE
All trialsøø (109 study arms§)	0.8837	0.6765	1.0402	0.107
SGLT2i, DPP4i, Pioglitazone or GLP1-RA in the active arm◇◇ (49 study arms*§)	0.8194	0.6887	0.9695	0.028

^*Excluding RCTs with outlier HRs for MACE, defined as HR ≥ 2.0 or HR ≤ 0.5.

^**Adjusted for Time since the diagnosis of T2DM, follow-up time and type of ADT in the active arm. Adjusting variables were selected for their association with HR for MACE in bivariate analyses.

^§Some RCTs had missing data for covariates.

^¥Data corresponds to sensitivity analysis 2, which excluded the following RCTs: TECOS, CAROLINA, SCORED, REWIND, EXCEL, DECLARE, CANVAS, and Dormandy (24).

^‡I²: 3.87%, QE = 90.0 (p = 0.99); tau2: 0.010 (SE = 0.022).

I²: 5.31%, QE = 8.7 (p = 0.37); tau2: 0.010 (SE = 0.022).

^øI²: 22.08%, QE = 91.3 (p = 0.99); tau2: 0.010 (SE = 0.022).

^◇I²: 5.31%, QE = 8.4 (p = 0.35); tau2: 0.010 (SE = 0.022).

^‡‡I²: 0%, QE = 70.1 (p = 0.94); tau2: 0.014 (SE = 0.012).

I²: 0%, QE = 5.6 (p = 0.21); tau2: 0.010 (SE = 0.021).

^øøI²: 0%, QE = 83.7 (p = 0.97); tau2: 0.018 (SE = 0.027).

^◇◇I²: 0%, QE = 6.1 (p = 0.28); tau2: 0.008 (SE = 0.028).