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. 2022 Apr 29;12:873532. doi: 10.3389/fonc.2022.873532

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Copyright © 2022 Khadse, Haakensen, Silwal-Pandit, Hamfjord, Micke, Botling, Brustugun, Lingjærde, Helland and Kure

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Kaplan–Meier survival plots for (A) overall survival (OS) and (B) relapse-free survival (RFS) in patients with lung adenocarcinomas with and without LOH in KRAS indicating improved survival with LOH in KRAS. (C) OS in patients with stage I disease. (D) OS in wild-type KRAS tumors and (E) KRAS mutated tumors. (F, G) OS and RFS in patients based on combined KRAS mutation and LOH status, where patients with both KRAS mutation and KRAS LOH (purple) have better OS and RFS, whereas patients with only KRAS mutation and no KRAS LOH (blue) have the worst OS as well as RFS.