Table 3.

Univariate and multivariate Cox proportional hazards regression analyses of different prognostic variables for overall survival (OS) and relapse-free survival (RFS) in early-stage lung adenocarcinoma.

Factors	Overall survival (OS)				Relapse-free survival (RFS)
	Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis
	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value
Age	1.031 (1.013–1.05)	<0.001	1.033 (1.013–1.054)	0.001	1.003 (0.978–1.029)	0.787	1.007 (0.979–1.036)	0.624
Sex (male vs. female)	1.044 (0.763–1.427)	0.788	NA		0.988 (0.639–1.529)	0.958	NA
Stage (II + III vs. I)	1.327 (0.965–1.823)	0.081	1.305 (0.898–1.897)	0.162	2.121 (1.377–3.267)	<0.001	1.959 (1.204-3.188)	0.007
ECOG (1 + 2 + 3 vs. 0)	1.266 (0.907–1.765)	0.165	NA		0.701 (0.426–1.152)	0.161	NA
Genome instability index (high vs. low)	0.913 (0.427–1.951)	0.814	NA		1.456 (0.524–4.045)	0.471	NA
EGFR mutation (present vs. absent)	0.915 (0.583–1.436)	0.698	NA		0.787 (0.406–1.526)	0.478	NA
KRAS expression	1.106 (0.905–1.335)	0.297	0.987 (0.792–1.230)	0.908	1.212 (0.953–1.541)	0.118	1.017 (0.771–1.342)	0.903
KRAS mutation (present vs. absent)	1.224 (0.889–1.685)	0.214	1.316 (0.892–1.940)	0.165	1.261 (0.812–1.957)	0.302	1.324 (0.791–2.218)	0.285
KRAS LOH (present vs. absent)	0.653 (0.449–0.948)	0.025	0.694 (0.456–1.056)	0.088	0.637 (0.385–1.055)	0.08	0.705 (0.398–1.249)	0.230

Statistically significant p-values in bold. NA, Not applicable.