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. 2022 Apr 29;13:858805. doi: 10.3389/fneur.2022.858805

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Copyright © 2022 Sun, Jiang, Liu, Muccio, Li, Cao, Wisniewski, Lu and Ge.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Univariate linear regression plot of left ICA (LICA) as a representative vessel to show the coefficient difference between males (blue) and females (red). (A) The TI of LICA has a positive correlation with age (coeff = 0.018, P < 0.001, black dash line), and the linear correlation coefficients for males and females are 0.014 and 0.023, respectively. (B) Bending length (BL) of LICA is negatively correlated with age (coeff = 0.30, p < 0.001, black dash line), and the linear correlation coefficients for males and females are 0.246 and 0.379, respectively. (C) The ICM of LICA has significantly positive correlation with age (coeff = 0.072, p < 0.001, black dash line). The coefficients for males and females are 0.048 and 0.087. (D) The MaxV of LICA is negatively correlated with age (coeff = −0.247, p < 0.001, black dash line), and coefficients for males and females are −0.182 and −0.282.