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. 2022 Apr 29;14:877078. doi: 10.3389/fnagi.2022.877078

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Copyright © 2022 Wang, Zhu, Wang, Li, Yi, Wang, Fan, Tang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PCA score plot of all analyzed samples in positive-ion (A) mode and negative-ion (B) mode with the statistical parameters; VIP of OPLS-DA between the control and model groups in positive-ion (C) mode and negative-ion (D) mode; VIP of OPLS-DA between the model and Cy-3-G-H groups in positive-ion (E) mode and negative-ion (F) mode; Bubble chart of GO function analysis (G) and the metabolites statistics of KEGG (H).