Table 2.
Association between WHO score and MIRNA sequences. The results are reported as crude and sex- and age-adjusted incidence rate ratio (IRR) values and corresponding 95% confidence intervals (95% CIs)
| WHO score ≥ 5 (N = 27) |
WHO score < 5 (N = 29) |
IRRa (95% CI) |
Adjusted IRR (95% CI) |
|
|---|---|---|---|---|
| TTV DNA, copies/ml | ||||
| Negative (= 10), N (%) | 12 (44) | 11 (38) | Ref. | Ref. |
| Positive (> 10), N (%) | 15 (56) | 18 (62) | 0.87 (0.51–1.50) | 0.84 (0.47–1.51) |
| miRNA t1a, copies/ug RNA | ||||
| Negative (= 10), N (%) | 20 (74) | 19 (66) | Ref. | Ref. |
| Positive (> 10), N (%) | 7 (26) | 10 (34) | 0.80 (0.42–1.53) | 0.77 (0.41–1.44) |
| miRNA t3b, copies/ug RNA | ||||
| Negative (= 10), N (%) | 7 (26) | 13 (45) | Ref. | Ref. |
| Positive (> 10), N (%) | 20 (74) | 16 (55) | 1.58 (0.82–3.09) | 1.46 (0.74–2.88) |
| miRNA tth8, copies/ug RNAb | ||||
| ≤ 3080, N (%) | 10 (37) | 20 (69) | Ref. | Ref. |
| > 3080, N (%) | 17 (63) | 9 (31) | 1.96 (1.10–3.50) | 2.04 (1.14–3.63) |
aIncidence rate ratio (IRR) was calculated using Poisson regression models with robust variance
bAs the TTV miRNA tth8 exhibited a low number of negative values, the median values (3080 copies/μg RNA) obtained using all positive data was used for dichotomous variables. Thus, for miRNA tth8, the data reported in the WHO score ≥ 5 and WHO score < 5 were the number of samples with values ≤ 3080 and those > 3080