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. 2022 Apr 29;9:891659. doi: 10.3389/fmed.2022.891659

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Copyright © 2022 Suzuki, Arinaga-Hino, Sano, Mihara, Kusano, Mizuochi, Togawa, Ito, Ide, Kuwahara, Amano, Kawaguchi, Yano, Kage, Koga and Torimura.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histopathologic findings in the liver. (A) Liver tissue showed no significant lobular architecture (hematoxylin and eosin staining). Scale bar represents 50 μm. (B) Cholestasis was observed in the hepatocytes, Kupffer cells, and bile canaliculi at zones 2 and 3 (hematoxylin and eosin staining). Scale bar represents 20 μm. (C) There was no significant fibrosis (Azan staining). Scale bar represents 100 μm. (D–F) Immunohistochemistry for bile salt export pump (D), CD10 (E), and keratin 7 (F). The strong expression of bile salt export pump and CD10 were observed at the canalicular membrane (D,E). The keratin 7 expression was found in the hepatocytes in the periportal areas. The intralobular bile duct arrangement was preserved (F). Scale bars represent 50 μm.