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. 2022 Apr 27;14(4):729–743. doi: 10.4254/wjh.v14.i4.729

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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Effect of baicalin on serum inflammatory markers in fluoxetine treated rats. A: Tumor necrosis factor-α; B: Interleukin (IL)-6; C: IL-10; D: Interferon-γ. The values are expressed in pg/mL. Group 1: Control rats; group 2: Fluoxetine treated rats (10 mg/kg); group 3: Fluoxetine (10 mg/kg) + baicalin (50 mg/kg); group 4: Fluoxetine (10 mg/kg) + baicalin (100 mg/kg); group 5: Fluoxetine (10 mg/kg) + silymarin (100 mg/kg); group 6: Baicalin (100 mg/kg); group 7: Silymarin (100 mg/kg). Data represent mean ± SD, n = 6. ^aRepresents a significant difference compared with group 1, P < 0.05; ^brepresents a significant difference compared with group 2, P < 0.05; ^crepresents a significant difference compared with group 2, P < 0.005; ^drepresents a significant difference compared with group 2, P < 0.0001. TNF: Tumor necrosis factor; IL: Interleukin; IFN: Interferon.