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. 2022 Apr 27;14(4):729–743. doi: 10.4254/wjh.v14.i4.729

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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Histological sections of rat liver. A: Normal control (the black arrow shows normal intercellular spaces and negligible vacuolation); B: Fluoxetine (10 mg/kg) treated (the black arrows show increased vacuolation and cellular degeneration, blue arrows indicate presence of inflammatory cells); C: Fluoxetine + baicalin (50 mg/kg) treated (blue arrows indicate a patch of inflammatory cell infiltration); D: Fluoxetine + baicalin (100 mg/kg) treated (the black arrow depicts regular cellular pattern and normal sinusoidal space, blue arrow indicates fewer inflammatory cells); E: Fluoxetine + silymarin (100 mg/kg) treated (the black arrows show normal cells and intercellular spaces similar to normal control); F: Baicalin (100 mg/kg) treated (the black arrows show normal cellular structure); G: Silymarin (100 mg/kg) treated (the black arrows depict normal cells and intercellular spaces).