Table 3.
Performance of indirect periportal fibrosis markers in Schistosomiasis mansoni infected patients
| Marker | Parameters |
Performance in S. mansoni infected patients
|
|||||
|
Severe PPF
|
Mild/significant PPF
|
||||||
|
Cut-off
|
Sn (%)
|
Sp (%)
|
Cut-off
|
Sn (%)
|
Sp (%)
|
||
| Platelet count[17,26] | Platelet count/mm3 | 141000[17] | 78.5 | 60 | 171000[17], 108500[26] | 80, 91 | 91.7, 85 |
| APRI[17,26] | (AST/ULN)/platelet count | 1.066 | 58.5 | 71.1 | 0.349[17], 0.440[26] | 90, 96 | 83.3, 85 |
| GGT[17] | GGT/ULN | > 1.55 | 60.0 | 75.6 | > 0.84 | 74.6 | 83.3 |
| Coutinho index[29,30] | (ALP/ULN)/platelet count | ≥ 0.330[29], ≥ 0.316[30] | 98, 67.4 | 94.7, 68.3 | ≥ 0.300, ≥ 0.228 | 70.8, 68.6 | 89.5, 46.3 |
APRI: Aspartate aminotransferase to platelet ratio index; ALP: Alkaline phosphatase; GGT: Gamma glutamyl transferase; PPF: Periportal fibrosis; Sn: Sensitivity; Sp: Specificity; ULN: Upper limit of normality; S. mansoni: Schistosomiasis mansoni.