Table 2.
Ref.
|
MELD or MELD delta (last visit-baseline)
|
SAE
|
No. of hospitalized patients
|
Ammonia level (mean µ/dL )
|
HE episodes
|
Cognitive assessment (s): Encephaloapp stroop test (low is good) (t = time, Δt: Change in time)
|
Cognitive assessment (points): PHES score (high is good) (p = points, Δp: Change in points)
|
Bajaj et al[29], 2019 | 2.8 + (-4.5) | 1 | 0 at median 1 yr | NA | 0 at median 1 yr | Day 0: 245; day 20: 200; t > 1 yr: 225 | Day 0: -7; day 20: -4; P > 1 yr: -6 |
2.78 + (-4.7) | 3 | 10 at median 1 yr | NA | 1.5 at median 1 yr | Day 0: 260; day 20: 250; t > 1 yr: 250 | Day 0: -8; day 20: -8; P > 1 yr: -11 | |
Bajaj et al[28], 2017 | 0.1 + (-2) | 2 | 1 | NA | 0 at 0.4 yr | Day 0: 247; day 0-20: 29.1 ± 27.9 | Day 0: -7.4; day 0-20: (-3.1) ± (-2.1) |
-0.2 + (-2.7) | 8 | 9 | NA | 6 at 0.4 yr | Day 0: 282; day 0-20: (-43.5) ± (-95.7) | Day 0: -8.6; day 0-20: 0.0 ± 3.1 | |
Woodhouse et al[33], 2019 | No significant change | 4 | 4 at day 30 | Day 0: 71; day 30: 51 | NA | NA | NA |
No significant change | 1 | 1 at day 30 | Day 0: 54; day 30: 73 | NA | NA | NA | |
Bloom et al[81], 2019 | 14.3 ± 3.3 | 1 | NA | No significant change | NA | Day 0: 56; day 30: 22 | Day 7: 2.6; day 30: 3.9 |
NA | NA | NA | No significant change | NA | NA | NA | |
Mehta et al[30], 2018 | 15 | 4 | 2 by 20 wk | Day 0: 96; day 20: 74 | 3 by 20 wk | NA | NA |
Kao et al[32], 2016 | NA | 0 | 1 | Day 0: 75; day 20: 45 | 0 | Day 0: 250.9; day 7: 203.4 | NA |
MELD: Model for end-stage liver disease; HE: Hepatic encephalopathy; NA: Not available.