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Proposed SARS-CoV-2 N protein-mediated RNP packaging mode. (A) Dimerization is mediated by the CTD domain. (B) Dimers self-associate through the LKR region to form homotetramers. (C) Proposed RNA-binding octamers mode. The yellow line represents the viral RNA strand wrapped around the helical supercomplex nucleocapsid protein. (D) SR-motif phosphorylation, i.e., nucleocapsid protein dissociation from RNP, exposes genomic RNA for replication.
