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. 2022 Apr 29;9:815866. doi: 10.3389/fmed.2022.815866

FIGURE 1.

FIGURE 1

Experimental setup and real-time pressure-dependent optical coherence tomography (OCT) images. (A) A tissue wedge in a Petri dish with the trabecular meshwork (TM) facing upward during high-resolution OCT imaging. A micromanipulator guides one end of a cannula to the wedge and holds it securely in Schlemm’s canal (SC). The opposite end of the cannula leads to a valve that switches between two reservoirs, one at 0 mm Hg and the other at 30 mm Hg. OCT imaging is initiated before switching reservoirs and continues until achieving a new steady-state tissue configuration. (B,C) OCT images at 0 and 30 mm Hg, respectively, from the distal SC location, are noted in Figure 2. Both SC and collector channels (CC) collapse at 0 mm Hg but markedly enlarge when pressure increases in SC.