Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Apr 29;10:886718. doi: 10.3389/fcell.2022.886718

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Christie, Fijen and Rothenberg.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Schematic overview of Non-Homologous End Joining. (A) Broken DNA ends are recognized by Ku and DNA-PKcs. Hairpins in coding ends are opened by the Artemis nuclease. (B) Ends are brought in close proximity in a process called synapsis. XLF and XRCC4 are thought to form filaments that mediate this process. As discussed in the text, ATM, the RAG2 C-terminus and H2AX also have a role in synapsis. (C) Ends are ligated by Ligase IV. PAXX joins in this stage of repair. Please note that, while care was taken to represent the architecture of the complexes as accurately as possible, many structural features still remain unknown.