Table 1.
Basic characteristics of the included studies.
| Study design | Sample size | Mean age, years (T/N) | Gender(M/F) | Intravenous thrombolysis | Endovascular therapy | The reasons for administration of tirofiban | Tirofiban protocol | |||
|---|---|---|---|---|---|---|---|---|---|---|
| T | N | T | N | |||||||
| Yi et al. (16) |
Observational | 22 | 111 | na | na | IV t-PA | Stent retrieval | According to “tirofiban administration during mechanical thrombectomy” | A intra-arterial bolus (0.25–1 mg) followed by continuous intravenous infusion of 0.05 μg/kg/min for 24 h | |
| Huo et al. (17) | Observational | 55 | 152 | 62.5/64.4 | 38/17 | 104/48 | IVT | Stent retrieval or contact aspiration | According to “tirofiban administration during mechanical thrombectomy” | A intra-arterial bolus (0.25–1 mg) followed by continuous intravenous infusion of 0.1 μg/kg/min for 12–24 h |
| Jang et al. (18) | Observational | 35 | 279 | 66/69 | 24/11 | 144/135 | IV t-PA | Stent retrieval or contact aspiration | According to “tirofiban administration during mechanical thrombectomy” | A bolus at artery of 1 mL/min (dose range of 0.25–2.0 mg) |
| Ma et al. (19) | Observational | 81 | 120 | 62/65 | 52/29 | 78/42 | IVT | Stent retrieval or contact aspiration | According to “tirofiban administration during mechanical thrombectomy” | A intra-arterial bolus (0.25–1 mg) followed by continuous intravenous infusion of 0.1 μg/kg/min for 24 h |
| Gao et al. (20) | Observational | 45 | 76 | Na | na | IV t-PA | Stent retrieval | Determined by study protocol | A intra-arterial bolus (6 ug/kg) followed by continuous intravenous infusion of 0.1 μg/kg/min for 24 h | |
| Yan et al. (21) | Observational | 62 | 58 | 61.34 | 38/24 | 32/26 | IV t-PA | Stent retrieval | Determined by study protocol | A intra-arterial bolus (10 ug/kg) followed by continuous intravenous infusion of 0.15 μg/kg/min for 24 h |
| Guo qiang et al. (22) | RCT | 40 | 40 | 58.2 | 24/16 | 22/18 | IV t-PA | Stent retrieval | Determined by study protocol | A intra-arterial bolus (6 ug/kg) followed by continuous intravenous infusion of 0.1 μg/kg/min for 24 h |
T, tirofiban group; N, non-tirofiban group; MT, mechanical thrombectomy; EVT, endovascular treatment; IVT, intravenous thrombolysis; na, not available; IVt-PA, intravenous tissue plasminogen activator.