TABLE 1.
Metabolism kinetics of BPA found in the literature.
| References | V max | K M (µM) | CLint_invitro | CLint_invivo (L/h) a | Metabolic system |
|---|---|---|---|---|---|
| Kuester and Sipes (2007) | 438 pmol/min/106 cells | 9 | 56 μl/min/106 cells | 590 b | Cryopreserved hepatocytes |
| Elsby et al. (2001) | 5.9 nmol/min/mg protein | 77.5 | 292 c | Pooled liver microsomes | |
| Kurebayashi et al. (2010) | 10.6 ml/h/106 cells | 5.3 | 2 ml/h/106 cells | 351 b | Cryopreserved hepatocytes |
| Trdan Lušin et al. (2012) | 8.5 nmol/min/mg protein | 8.9 | 0.95 ml/min/mg protein | 3637 c | Liver microsomes |
| Mazur et al. (2010) | 2077 pmol/min/mg protein | 3.6 | 649 μl/min/mg protein | 2486 c | Liver microsomes |
| Rotroff et al. (2010) | 25.04 μl/min/106 cells | 264 b | Hepatocytes |
a
Calculated V max = maximal velocity of metabolic clearance; K M, Michaelis-Menten parameter (half-maximal metabolism concentration)
b
CLint_invivo = CLint_invitro × HPGL (hepatocytes per gram liver: 110 million cells/g liver) × Volume liver (1,596 g) × 60 min/h.
c
CLint_invivo = CLint_invitro × MPPGL (mg of microsome protein/g liver: 40) × Volume liver (1,596 g) × 60 min/h.