| 1.1 Stem cell therapy versus placebo or control, Outcome: Clinical remission |
3 |
301 |
Risk Ratio (M‐H, Random, 95% CI) |
1.88 [0.80, 4.41] |
| 1.2 CDAI <150 at 24 weeks |
4 |
352 |
Risk Ratio (M‐H, Random, 95% CI) |
1.02 [0.67, 1.56] |
| 1.3 Stem cell therapy versus placebo or control, Outcome: Fistula Closure short‐term |
4 |
269 |
Risk Ratio (M‐H, Random, 95% CI) |
1.48 [1.12, 1.96] |
| 1.4 Stem cell therapy versus placebo or control, Outcome: Fistula closure in long‐term Follow up of original studies |
4 |
250 |
Risk Ratio (M‐H, Random, 95% CI) |
1.42 [1.09, 1.87] |
| 1.5 PDAI Change at week 12 |
3 |
|
Mean Difference (IV, Random, 95% CI) |
Totals not selected |
| 1.6 PDAI change at week 24 |
3 |
247 |
Mean Difference (IV, Random, 95% CI) |
‐0.35 [‐1.57, 0.86] |
| 1.7 CDAI change at 24 weeks |
5 |
|
Mean Difference (IV, Random, 95% CI) |
Totals not selected |
| 1.8 Harvey Bradshow Index (HBI) change after 12 months |
2 |
124 |
Mean Difference (IV, Random, 95% CI) |
‐2.59 [‐4.04, ‐1.14] |
| 1.9 Endoscopic score change after 12 weeks |
3 |
|
Std. Mean Difference (IV, Random, 95% CI) |
Totals not selected |
| 1.10 Total Adverse Events |
4 |
293 |
Risk Ratio (M‐H, Random, 95% CI) |
0.99 [0.88, 1.13] |
| 1.11 Serious Adverse Events |
7 |
433 |
Risk Ratio (M‐H, Random, 95% CI) |
1.22 [0.88, 1.67] |
| 1.12 Withdrawal due to adverse events |
3 |
272 |
Risk Ratio (M‐H, Random, 95% CI) |
0.78 [0.32, 1.89] |
| 1.13 All cause mortality |
7 |
440 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
5.51 [0.30, 101.02] |
| 1.14 Quality of life score (change from base line) IBDQ |
4 |
292 |
Std. Mean Difference (IV, Random, 95% CI) |
0.25 [‐0.18, 0.68] |
