Outcome	Random effect	Fixed effect	With high risk	Without high risk
Clinical remission	1.88 [0.80, 4.41]	1.47 [1.10, 1.95]		1.41 [1.06, 1.88] Melmet 2015 (high randon and allocation)
CDAI <150	1.02 [0.67, 1.56]	1.08 [0.94, 1.24]		1.02 [0.67, 1.56] Zhang 2018 high blinding and detection unclear allocation
Fistula closure short	1.48 [1.12, 1.96]	1.53 [1.15, 2.03]		1.47 [1.07, 2.01] Garcia 2009 and Zhou 2020 unclear allocation and high blinding and detection
Fistula closure long	1.42 [1.09, 1.87]	1.47 [1.12, 1.94]		1.48 [1.10, 1.99] removing Garcia 2009 and Zhou 2020