Summary of findings 1. Summary of findings table ‐ Ibuprofen 1600 mg compared to paracetamol 2000 mg for women having medical abortion before 14 weeks? gestation.
| Ibuprofen 1600 mg compared to paracetamol 2000 mg for women having medical abortion before 14 weeks' gestation | ||||||
| Patient or population: women having medical abortion before 14 weeks' gestation Setting: clinic, Israel Intervention: Ibuprofen 1600 mg Comparison: Paracetamol 2000 mg | ||||||
| Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | № of participants (studies) | Certainty of the evidence (GRADE) | Comments | |
| Risk with Paracetamol 2000 mg | Risk with Ibuprofen 1600 mg | |||||
| Pain score | The mean pain score was 5.67 out of 10 | MD 2.26 out of 10 lower (3 lower to 1.52 lower) | ‐ | 108 (1 RCT) | ⊕⊕⊕⊝ Moderatea | |
| Gastrointestinal side effects (nausea) ‐ not reported | ‐ | ‐ | ‐ | ‐ | ‐ | |
| Gastroinestinal side effects (vomiting) ‐ not reported | ‐ | ‐ | ‐ | ‐ | ‐ | |
| Gastrointestinal side effects (diarrhoea) ‐ not reported | ‐ | ‐ | ‐ | ‐ | ‐ | |
| Complete abortion rate | 837 per 1000 | 915 per 1000 (766 to 973) | OR 2.11 (0.64 to 6.92) | 108 (1 RCT) | ⊕⊕⊝⊝ Lowb | |
| Induction to expulsion interval ‐ not reported | ‐ | ‐ | ‐ | ‐ | ‐ | |
| Unscheduled contact with care ‐ not reported | ‐ | ‐ | ‐ | ‐ | ‐ | |
| Patient satisfaction with analgesia ‐ not reported | ‐ | ‐ | ‐ | ‐ | ‐ | |
| Patient satisfaction with abortion care overall ‐ not reported | ‐ | ‐ | ‐ | ‐ | ‐ | |
| *The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; MD: mean difference; OR: odds ratio | ||||||
| GRADE Working Group grades of evidence High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect. | ||||||
| See interactive version of this table: https://gdt.gradepro.org/presentations/#/isof/isof_question_revman_web_419478415248553147. | ||||||
a Downgraded 1 level for imprecision: small sample size. b Downgraded 2 levels for imprecision: small sample size and 95% confidence intervals include no effect.