Summary of findings 2. Summary of findings table ‐ Pregabalin 300 mg compared to placebo for women having medical abortion before 14 weeks? gestation.
| Pregabalin 300 mg compared to placebo for women having medical abortion before 14 weeks' gestation | ||||||
| Patient or population: women having medical abortion before 14 weeks' gestation Setting: clinic, USA Intervention: pregabalin 300 mg Comparison: placebo | ||||||
| Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | № of participants (studies) | Certainty of the evidence (GRADE) | Comments | |
| Risk with placebo | Risk with pregabalin 300 mg | |||||
| Pain score | The mean pain score was 5.5 out of 10 | MD 0.5 out of 10 lower (1.41 lower to 0.41 higher) | ‐ | 107 (1 RCT) | ⊕⊕⊝⊝ Lowa | |
| Gastrointestinal side effects (nausea) | 808 per 1000 | 781 per 1000 (581 to 902) | OR 0.85 (0.33 to 2.19) | 107 (1 RCT) | ⊕⊕⊝⊝ Lowa | |
| Gastrointestinal side effects (vomiting) | 577 per 1000 | 509 per 1000 (323 to 690) | OR 0.76 (0.35 to 1.63) | 107 (1 RCT) | ⊕⊕⊝⊝ Lowa | |
| Gastrointestinal side effects (diarrhoea) | 558 per 1000 | 508 per 1000 (324 to 689) | OR 0.82 (0.38 to 1.76) | 107 (1 RCT) | ⊕⊕⊝⊝ Lowa | |
| Complete abortion rate ‐ not reported | ‐ | ‐ | ‐ | ‐ | ‐ | |
| Induction to expulsion interval ‐ not reported | ‐ | ‐ | ‐ | ‐ | ‐ | |
| Unscheduled contact with care ‐ not reported | ‐ | ‐ | ‐ | ‐ | ‐ | |
| Patient satisfaction with analgesia | 686 per 1000 | 680 per 1000 (479 to 829) | OR 0.97 (0.42 to 2.21) | 104 (1 RCT) | ⊕⊕⊝⊝ Lowa | |
| Patient satisfaction with abortion care overall | 608 per 1000 | 740 per 1000 (554 to 867) | OR 1.84 (0.80 to 4.22) | 105 (1 RCT) | ⊕⊕⊝⊝ Lowa | |
| *The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; MD: mean difference; OR: odds ratio | ||||||
| GRADE Working Group grades of evidence High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect. | ||||||
| See interactive version of this table: https://gdt.gradepro.org/presentations/#/isof/isof_question_revman_web_419478335724549023. | ||||||
a Downgraded 2 levels for imprecision: small sample size and 95% confidence intervals include no effect.