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. 2022 May 13;2022(5):CD013525. doi: 10.1002/14651858.CD013525.pub2

Summary of findings 3. Summary of findings table ‐ Ibuprofen 800 mg compared to placebo for women having medical abortion before 14 weeks? gestation.

Ibuprofen 800 mg compared to placebo for women having medical abortion before 14 weeks' gestation
Patient or population: women having medical abortion before 14 weeks' gestation
Setting: clinic, Israel
Intervention: Ibuprofen 800 mg
Comparison: Placebo
Outcomes Anticipated absolute effects* (95% CI) Relative effect
(95% CI) № of participants
(studies) Certainty of the evidence
(GRADE) Comments
Risk with Placebo Risk with Ibuprofen 800 mg
Pain score The mean pain score was 5.4 out of 10 MD 1.4 out of 10 lower
(3.33 lower to 0.53 higher) 61
(1 RCT) ⊕⊕⊝⊝
Lowa  
Gastrointestinal side effects (nausea) 594 per 1000 690 per 1000
(436 to 865) OR 1.52
(0.53 to 4.37) 61
(1 RCT) ⊕⊕⊝⊝
Lowa  
Gastrointestinal side effects (vomiting) 281 per 1000 69 per 1000
(15 to 275) OR 0.19
(0.04 to 0.97) 61
(1 RCT) ⊕⊕⊝⊝
Lowa  
Gastrointestinal side effects (diarrhoea) ‐ not reported  
Complete abortion rate 875 per 1000 828 per 1000
(543 to 952) OR 0.69
(0.17 to 2.85) 61
(1 RCT) ⊕⊕⊝⊝
Lowa  
Induction to expulsion interval ‐ not reported  
Unscheduled contact with care ‐ not reported  
Patient satisfaction with analgesia ‐ not reported  
Patient satisfaction with abortion care overall ‐ not reported  
*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).

CI: confidence interval; MD: mean difference; OR: odds ratio
GRADE Working Group grades of evidenceHigh certainty: we are very confident that the true effect lies close to that of the estimate of the effect.
Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different.
Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect.
Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect.
See interactive version of this table: https://gdt.gradepro.org/presentations/#/isof/isof_question_revman_web_419429983861681120.

a Downgraded 2 levels for imprecision: small sample size and wide 95% confidence intervals including no effect or very small effects.