Summary of findings 3. Summary of findings table ‐ Ibuprofen 800 mg compared to placebo for women having medical abortion before 14 weeks? gestation.
Ibuprofen 800 mg compared to placebo for women having medical abortion before 14 weeks' gestation | ||||||
Patient or population: women having medical abortion before 14 weeks' gestation Setting: clinic, Israel Intervention: Ibuprofen 800 mg Comparison: Placebo | ||||||
Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | № of participants (studies) | Certainty of the evidence (GRADE) | Comments | |
Risk with Placebo | Risk with Ibuprofen 800 mg | |||||
Pain score | The mean pain score was 5.4 out of 10 | MD 1.4 out of 10 lower (3.33 lower to 0.53 higher) | ‐ | 61 (1 RCT) | ⊕⊕⊝⊝ Lowa | |
Gastrointestinal side effects (nausea) | 594 per 1000 | 690 per 1000 (436 to 865) | OR 1.52 (0.53 to 4.37) | 61 (1 RCT) | ⊕⊕⊝⊝ Lowa | |
Gastrointestinal side effects (vomiting) | 281 per 1000 | 69 per 1000 (15 to 275) | OR 0.19 (0.04 to 0.97) | 61 (1 RCT) | ⊕⊕⊝⊝ Lowa | |
Gastrointestinal side effects (diarrhoea) ‐ not reported | ‐ | ‐ | ‐ | ‐ | ‐ | |
Complete abortion rate | 875 per 1000 | 828 per 1000 (543 to 952) | OR 0.69 (0.17 to 2.85) | 61 (1 RCT) | ⊕⊕⊝⊝ Lowa | |
Induction to expulsion interval ‐ not reported | ‐ | ‐ | ‐ | ‐ | ‐ | |
Unscheduled contact with care ‐ not reported | ‐ | ‐ | ‐ | ‐ | ‐ | |
Patient satisfaction with analgesia ‐ not reported | ‐ | ‐ | ‐ | ‐ | ‐ | |
Patient satisfaction with abortion care overall ‐ not reported | ‐ | ‐ | ‐ | ‐ | ‐ | |
*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; MD: mean difference; OR: odds ratio | ||||||
GRADE Working Group grades of evidence High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect. | ||||||
See interactive version of this table: https://gdt.gradepro.org/presentations/#/isof/isof_question_revman_web_419429983861681120. |
a Downgraded 2 levels for imprecision: small sample size and wide 95% confidence intervals including no effect or very small effects.