Summary of findings 5. Summary of findings table ‐ Therapeutic ibuprofen 800 mg compared to prophylactic ibuprofen 800 mg women having medical abortion before 14 weeks? gestation.
| Therapeutic ibuprofen 800 mg compared to prophylactic ibuprofen 800 mg women having medical abortion before 14 weeks' gestation | ||||||
| Patient or population: women having medical abortion before 14 weeks' gestation Setting: multiple clinics, USA Intervention: therapeutic ibuprofen 800 mg Comparison: prophylactic ibuprofen 800 mg | ||||||
| Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | № of participants (studies) | Certainty of the evidence (GRADE) | Comments | |
| Risk with prophylactic ibuprofen 800 mg | Risk with therapeutic ibuprofen 800 mg | |||||
| Pain score | The mean pain score was 7.1 out of 10 | MD 0.2 out of 10 higher (0.41 lower to 0.81 higher) | ‐ | 228 (1 RCT) | ⊕⊕⊝⊝ Lowa,b | |
| Gastrointestinal side effects (nausea and/or vomiting) | 378 per 1000 | 504 per 1000 (376 to 633) | OR 1.67 (0.99 to 2.83) | 228 (1 RCT) | ⊕⊕⊝⊝ Lowa,b | |
| Gastrointestinal side effects (diarrhoea) ‐ not reported | ‐ | ‐ | ‐ | ‐ | ‐ | |
| Complete abortion rate | 964 per 1000 | 974 per 1000 (892 to 994) | OR 1.42 (0.31 to 6.50) | 228 (1 RCT) | ⊕⊕⊝⊝ Lowa,b | |
| Induction to expulsion interval ‐ not reported | ‐ | ‐ | ‐ | ‐ | ‐ | |
| Unscheduled contact with care | 360 per 1000 | 367 per 1000 (253 to 499) | OR 1.03 (0.60 to 1.77) | 228 (1 RCT) | ⊕⊕⊝⊝ Lowa,b | |
| Patient satisfaction with analgesia ‐ not reported | ‐ | ‐ | ‐ | ‐ | ‐ | |
| Patient satisfaction with abortion care overall | 982 per 1000 | 966 per 1000 (831 to 994) | OR 0.52 (0.09 to 2.89) | 228 (1 RCT) | ⊕⊕⊝⊝ Lowa,b | |
| *The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; MD: mean difference; OR: odds ratio | ||||||
| GRADE Working Group grades of evidence High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect. | ||||||
| See interactive version of this table: https://gdt.gradepro.org/presentations/#/isof/isof_question_revman_web_419478610033865921. | ||||||
a Downgraded 1 level for risk of bias: high risk of bias due to lack of blinding of outcomes assessors b Downgraded 1 level for imprecision: 95% confidence interval includes no effect.