Raymond 2013.

Study characteristics
Methods	RCT
Participants	228 (117 therapeutic ibuprofen, 111 prophylactic ibuprofen) 250 women undergoing first‐trimester abortion with mifepristone and misoprostol at 3 clinics
Interventions	Women were assigned to 1 of 2 ibuprofen regimens: therapeutic (800 mg every 4‐6 h as needed for pain) or prophylactic (800 mg starting 1 h before the misoprostol dose, then every 4‐6 h for 48 h egardless of pain, then as needed)
Outcomes	Pain score, GI side effects, complete abortion
Notes	Trial registration: NCT01457521 (prospective) Dates: October 2011–December 2012 Funding: Society of Family Planning and an anonymous donor Conflicts of Interest: none disclosed Contact made to gather missing data: no further data available

GI: gastrointestinal; RCT: randomised controlled trial