Dragoman 2016.

Methods	"We propose a randomized, placebo‐controlled trial"
Participants	"576 participants (288 nulliparous; 288 parous) from study sites in Nepal, South Africa and Vietnam"
Interventions	"randomly allocated to one of three treatments: (1) ibuprofen 400 mg PO [orally] and metoclopramide 10 mg PO; (2) tramadol 50 mg PO and a placebo; or (3) two placebo pills, to be taken immediately before misoprostol and repeated once four hours later. All women will be provided with supplementary analgesia for use as needed during the medical abortion"
Outcomes	"We hypothesize that women receiving prophylactic analgesia will report lower maximal pain scores in the first 8 h following misoprostol administration compared to women receiving placebos for medical abortion through 63 days' gestation"
Notes