NCT02678897.

Methods	"Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment"
Participants	"Inclusion Criteria: Patients who choose medical method of abortion First pregnancy Age between 15 and 19 years or 25 and 35 years Patients volunteer in the study Exclusion criteria for inquiry part are Patient's serious illness Known allergy to one of the trial medications Abortion is done based on foetal abnormality or threat of patient's own health Exclusion criteria for intervention part are Abortion is done based on foetal abnormality or threat of patient's own health Minor patient does not want to inform guardian More than one foetus Patient's serious illness (ASA‐class 3 or 4) Massive obesity (BMI >35 kg/m2) Known allergy to one of the trial medications History of opioid abuse Problems of understanding (Inability of use PCA or to understand VAS) Active bleeding before intake of first Misoprostol dose One of next medications: ketokonatsol, erythromycin, claritromycin, verapamil or diltiazem or medication against HIV (CYP3A4‐transmitted interaction with oxycodon)"
Interventions	"Drug: Oxynorm on‐demand We compare different routes of administration (PCA an oral/intramuscular use of oxynorm) in patients undergoing medical termination of pregnancy. Patients are randomized in two groups (for extra pain medication) If analgesia is inadequate oxycodon (OxyNorm®) (10 mg (less than 80 kg) ‐ 15 mg (over 80 kg) po [orally]. In an hour oxycodon 5‐10 mg more po if needed. Intramuscular or intravenous administration if needed. Patient controlled analgesia (PCA pain pump): Oxycodon dose is 3.0 mg (3 ml) and lock‐out time 8 min. Maximum four doses in hour. Dose can be lowered or augmented 0,5 [0.5] mg at time between 2.0‐4.0 mg and maximal number of doses can be up to 5. Drug: Oxynorm via PCA We compare different routes of administration (PCA an oral/intramuscular use of oxynorm) in patients undergoing medical termination of pregnancy. Patients are randomized in two groups (for extra pain medication) If analgesia is inadequate oxycodon (OxyNorm®) (10 mg (less than 80 kg) ‐ 15 mg (over 80 kg) po. In an hour oxycodon 5‐10 mg more po if needed. Intramuscular or intravenous administration if needed. Patient controlled analgesia (PCA pain pump): Oxycodon dose is 3.0 mg (3 ml) and lock‐out time 8 min. Maximum four doses in hour. Dose can be lowered or augmented 0,5 [0.5] mg at time between 2.0‐4.0 mg and maximal number of doses can be up to 5."
Outcomes	Primary outcomes: "Patients are less painful using patient controlled analgesia (PCA) [ Time Frame: During drug‐induced abortion, in hospital care (1‐2days) ] Measured in visual analog scale (VAS, 0‐100mm). VAS is lower." Secondary outcomes: "Patient satisfaction is higher [ Time Frame: just after the abortion and 2‐3 weeks after in follow‐up visit ] Measured in visual analog scale (VAS, 0‐100mm), VAS is higher."
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