NCT03139240.

Study name	Opioid analgesia for MAB
Methods	"Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double (Participant, Investigator) Masking Description:Double Blind Primary Purpose: Treatment"
Participants	"Inclusion Criteria: Aged 18 years or older Seeking elective medical abortion In good health Pregnancy with intrauterine gestational sac up to 10 0/7 weeks, dated by ultrasound Able and willing to receive text messages via phone Literate in English Able and willing to give informed consent and agree to the study terms Have assistance at home; no motor vehicle use while taking study medications Exclusion Criteria: Lack of access to cell phone and texting capabilities Early pregnancy failure Contraindications to the study medications: Oxycodone, Ibuprofen Contraindications to medical abortion with Mifepristone or Misoprostol History of methadone or heroin use Used alcohol in the past 24 hours Used marijuana >4 times per week Any opioid in the past 30 days Using additional pain medications"
Interventions	"Drug: Oxycodone 10mg oral Oxycodone 10mg oral given for pain control in addition to standard of care medications in women undergoing medical abortion Other: Placebo Placebo given in addition to standard of care medications in women undergoing medical abortion"
Outcomes	"Overall Maximum Self‐reported Pain Score [ Time Frame: 24 hours after misoprostol administration ] Women text responses through two surveys within 24 hours after misoprostol administration indicating their maximum self‐reported pain score on an 11‐point Numeric Pain Rating Scale (0 = no pain, 5 = moderate pain, and 10 = worst possible pain). <7 Weeks of Gestation ‐ Maximum Self‐reported Pain Score [ Time Frame: 24 hours after misoprostol administration ] Women text responses through two surveys within 24 hours after misoprostol administration indicating their maximum self‐reported pain score on an 11‐point Numeric Pain Rating Scale (0 = no pain, 5 = moderate pain, and 10 = worst possible pain). 7‐10 Weeks Gestation ‐ Maximum Self‐reported Pain Score [ Time Frame: 24 hours after misoprostol administration ] Women text responses through two surveys within 24 hours after misoprostol administration indicating their maximum self‐reported pain score on an 11‐point Numeric Pain Rating Scale (0 = no pain, 5 = moderate pain, and 10 = worst possible pain)"
Starting date	01 May 2017
Contact information	Oregon Health and Science University
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