Table 2.

Odds ratio for death in ICU according to the mean glucose levels and glycemic variability on a continuous scale or in tertile groups.

ICU mortality		N	Event	Crude OR (95% CI)	P a	a.OR (95% CI)	P b	a.OR (95% CI)	P c	a.OR (95% CI)	P d
						Model 1		Model 2		Model 3
MBG	Glucose (per 20 mg/dl)	7,104	841	1.12 (1.08, 1.15)	<0.001	1.12 (1.08, 1.15)	<0.001	1.17 (1.13, 1.21)	<0.001	1.14 (1.09, 1.20)	<0.001
	Glucose (mg/dl)
	Glucose < =140	4,407	407	Ref		Ref		Ref		Ref
	Glucose >140 and <200	2,029	330	1.91 (1.63,2.23)	<0.001	1.88 (1.61, 2.19)	<0.001	2.16 (1.82, 2.55)	<0.001	1.97 (1.61, 2.41)	<0.001
	Glucose >=200	668	104	1.81 (1.43, 2.28)	<0.001	1.80 (1.42, 2.16)	<0.001	2.39 (1.83, 3.10)	<0.001	2.23 (1.64, 3.03)	<0.001
GLUcv	GLUcv (per 10%)	7,104	841	1.18 (1.13, 1.23)	<0.001	1.18 (1.13, 1.23)	<0.001	1.21 (1.16, 1.26)	<0.001	1.05 (1.00, 1.12)	0.05
	GLUcv %; (quartile: 25%, 75%)
	GLUcv <15.174	1,776	124	Ref		Ref		Ref		Ref
	GLUcv >=15.174 and < = 31.429	3,552	416	1.77 (1.44, 2.19)	<0.001	1.76 (1.43, 2.18)	<0.001	1.76 (1.43, 2.19)	<0.001	1.02 (0.81, 1.29)	0.86
	GLUcv >= 31.429	1,776	301	2.72 (2.19, 3.40)	<0.001	2.71 (2.18, 3.39)	<0.001	2.98 (2.37, 3.76)	<0.001	1.36 (1.04, 1.77)	0.03

Model 1: adjusted for age and gender.

Model 2: adjusted for age, gender and comorbidity.

Model 3: adjusted for age, gender, comorbidity, SOFA, APS III, Charlson Comorbidity Index, MBG/Glu_CV, septic shock or not, mechanical ventilation, renal replacement therapy, insulin infusion, NLR, and hypoglycemic event.

aOR and corresponding 95% CIs are presented in bold when the 95% CI cross 1.

^aP for crude analysis.

^bP for analysis based on Model 1.

^cP for analysis based on Model 2.

^dP for analysis based on Model 3.