Table 1.

Diagnostic criteria for acute necrotizing encephalopathy (ANE) contrasted to our patient's case.

Diagnostic criteria	Our patient
(1) Acute encephalopathy preceded by viral febrile disease; rapid deterioration in the level of consciousness or convulsions.	Fulfilled
(2) Increased CSF protein without pleocytosis.	Fulfilled
(3) CT or MRI evidence for symmetric, multifocal brain lesions. Involvement of the bilateral thalami. Lesions also common in the cerebral periventricular white matter, internal capsule, putamen, upper brainstem tegmentum and cerebellar medulla. No involvement of other CNS regions.	Fulfilled
(4) Elevation of serum aminotransferases of variable degrees. No increase in blood ammonia.	Unfulfilled
(5) Exclusion of other resembling diseases.	Fulfilled