Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Apr 29;13:848352. doi: 10.3389/fimmu.2022.848352

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Knijff, van Kooten and Ploeg

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

HMP influences several functions of the endothelium. After HMP or reperfusion (NMP or autotransplantation) there is less leukocyte trafficking compared to SCS treated organs (red line). Also less thrombotic factors, fibrosis and EMT were observed. However, the vascular tone was improved when organs were treated with HMP instead of SCS (green line). More studies are needed to confirm the effect of HMP on the glycocalyx (red dotted line). eNOS, endothelial nitric oxide synthase; ICAM, intercellular adhesion molecule; Ly6G, lymphocyte antigen 6 complex locus G6D; MCP-1, monocyte chemoattractant protein-1; NO, nitric oxide; TGF-β, transforming growth factor β; vWF, von Willebrand factor.