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The effect of HMP on dampening the immune response. HMP has shown to reduce sensing of DAMPs and pro-inflammatory cytokines compared to SCS (red line). Some studies suggest there might be an upregulation of anti-inflammatory cytokines and a reduction in circulating donor immune cells (green and red dotted line). The effect of HMP on the complement system is still unknown. DAMPs, damage-associated molecular patterns; HMGB1, high-mobility group box 1; TLR, Toll-like receptor.
