FIGURE 7.

KEGG pathway analysis. (A) Shown is a Venn diagram depicting the overlap of KEGG pathways differentially upregulated by various apoE lipoproteins. While there is a considerable overlap between the number of KEGG pathways upregulated by apoE2 or apoE3 and those upregulated by apoE3 or apoE4, there is no overlap between apoE2 and apoE4 and across all three apoE isoforms. Shown are heat maps of KEGG pathways, which are significantly upregulated (B) or downregulated (C) in neurons maturated in the presence of indicated apoE lipoproteins vs. the control neurons. Color intensity gradients included alongside each heatmap graphically represent negative Log₁₀ of p-values for enriched KEGG pathways.