TABLE 1.

– CLIF- Sequential Organ Failure Assessment (SOFA) score defining thresholds for organ failures (bold) to assess ACLF severity (20).

CLIF-sequential organ failure assessment (SOFA) score
Organ failure	0	1	2	3	4
Liver (bilirubin, mg/dl)	<1.2	≥1.2-<2.0	≥2-<6.0	≥6.0-<12.0	≥12.0
Kidney (creatinine, mg/dl)	<1.2	≥1.2-<2.0	≥2-<3.5	≥3.5-<5.0	>5.0 or RRT
Cerebral (HE grade)	No HE	HE grade I	HE grade II	HE grade III	HE grade IV
Coagulation (INR or PLT count)	<1.1	≥1.21 < 1.25	≥1.25-<1.5	≥1.5-<2.5	>2.5 or PLT count ≤20.000
Circulatory (MAP, mmHg and vasopressors)	≥70	<70	Dopamine ≤5* or dobutamine or terlipressin	Dopamine >5* or E ≤0.1* or NE ≤0.1*	Dopamine >15* or E >0.1* or NE >0.1*
Lung
PaO2/FiO2	>400	>300–≤400	>200–≤300	>100–≤200	≤100
SpO2/FiO2	>512	>357–≤512	>214–≤357	>89- ≤214	≤89