Table 3.
Univariable and Multivariable Cox Regression Analyses for Recurrences
| Variable | Univariable analysis | Multivariable analysis | |||
|---|---|---|---|---|---|
| HR (95% CI) | p-value | Adjusted HR (95% CI) | p-value | ||
| Surgical recurrence | |||||
| Early postop TNF-α inhibitors | 0.922 (0.096–8.864) | 0.944 | |||
| Concomitant azathioprine | 0.382 (0.054–2.719) | 0.336 | |||
| Time from diagnosis to initial surgery | 1.002 (0.979–1.027) | 0.849 | |||
| Time from diagnosis to the first TNF-α inhibitors | 1.021 (0.991–1.051) | 0.169 | 1.021 (0.991–1.051) | 0.169 | |
| Smoking history | NA* | ||||
| Family history | NA* | ||||
| Perianal disease | 1.388 (0.144–13.348) | 0.776 | |||
| B3 (penetrating) | 0.883 (0.124–6.269) | 0.901 | |||
| A1 (<16 yr) | NA* | ||||
| Clinical recurrence | |||||
| Early postop TNF-α inhibitors | 0.194 (0.057–0.656) | 0.008 | 0.204 (0.060–0.691) | 0.011 | |
| Concomitant azathioprine | 0.436 (0.186–1.023) | 0.056 | 0.564 (0.228–1.393) | 0.214 | |
| Time from diagnosis to initial surgery | 1.006 (0.997–1.015) | 0.177 | 1.003 (0.994–1.013) | 0.501 | |
| Time from diagnosis to the first TNF-α inhibitors | 1.004 (0.992–1.015) | 0.544 | |||
| Smoking history | 1.425 (0.478–4.252) | 0.526 | |||
| Family history | 1.300 (0.170–9.968) | 0.801 | |||
| Perianal disease | 2.047 (0.753–5.562) | 0.160 | 1.626 (0.562–4.708) | 0.370 | |
| B3 (penetrating) | 1.235 (0.527–2.890) | 0.627 | |||
| A1 (<16 yr) | 0.370 (0.050–2.751) | 0.331 | |||
HR, hazard ratio; CI, confidence interval; TNF, tumor necrosis factor.
*NA: data not available for statistical analysis due to the small number of surgical recurrences.