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. 2022 Apr 29;13:864481. doi: 10.3389/fpsyt.2022.864481

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Copyright © 2022 Yi, Zou, Meng, Chen, Hong, Liu, Farooq, Chen, Lin, Zhou, Ao, Hu and Niu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The determination of LPS experimental dose. (A) Motion trail of mice injected with saline and different dose of LPS. (B) Compared with mice injected saline, the number of entries in the central zone of LPS-injected mice was decreased, indicating depressive-like behaviors (n = 9 in each group). The depressive-like behaviors of mice injected with 1 mg/kg LPS was more obvious. LPS, lipopolysaccharide. **p < 0.01; ****p < 0.0001.