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. 2022 Apr 29;13:864481. doi: 10.3389/fpsyt.2022.864481

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Copyright © 2022 Yi, Zou, Meng, Chen, Hong, Liu, Farooq, Chen, Lin, Zhou, Ao, Hu and Niu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of LPS and US on the behavior of healthy and depressed mice. (A) Schematic diagram of the OFT. (B) The total distance traveled in 5 min is significantly decreased in LPS-treated mice compared with mice injected saline. Schematic diagrams of the FST (C) and TST (E). After US treatment, immobility time in the FST (D) and TST (F) is significantly reduced 24 h after LPS injection. LPS, lipopolysaccharide; US, ultrasound stimulation; PFC, prefrontal cortex; OFT, open field test; FST, forced swimming test; TST, tail suspension test. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.