Table 1.
Clinicopathological data of cN0 UTUC patients receiving nephroureterectomy.
| Variables | LND (-) (N=463) | LND (+) (N=195) | p valuea | ||
|---|---|---|---|---|---|
| N | % | N | % | ||
| Gender | 0.166 | ||||
| Men | 196 | (42.3) | 94 | (48.2) | |
| Women | 267 | (57.7) | 101 | (51.8) | |
| Ageb Mean ±SD | 69.8±10.8 | 67.7±10.6 | 0.022* | ||
| ECOG scores | <0.001** | ||||
| 0 | 188 | (40.6) | 40 | (20.5) | |
| 1 | 214 | (46.2) | 130 | (66.7) | |
| 2 | 47 | (10.2) | 23 | (11.8) | |
| 3 | 9 | (1.9) | 2 | (1.0) | |
| 4 | 5 | (1.1) | 0 | (0.0) | |
| Tumor location | 0.466 | ||||
| Renal pelvis | 217 | (47.1) | 94 | (48.5) | |
| Ureter | 163 | (35.4) | 60 | (30.9) | |
| Synchronous | 81 | (17.6) | 40 | (20.6) | |
| Tumor size | 0.266 | ||||
| non-visible | 2 | (0.4) | 1 | (0.5) | |
| <1cm | 14 | (3.0) | 3 | (1.5) | |
| ≥1 & < 2 cm | 81 | (17.5) | 33 | (16.9) | |
| ≥2 & < 3 cm | 117 | (25.3) | 37 | (19.0) | |
| ≥ 3cm | 249 | (53.8) | 121 | (62.1) | |
| Histological variant | 0.008** | ||||
| No | 409 | (88.3) | 157 | (80.5) | |
| Yes | 54 | (11.7) | 38 | (19.5) | |
| Tumor grade | 0.166 | ||||
| Low grade | 35 | (7.6) | 9 | (4.6) | |
| High grade | 427 | (92.4) | 186 | (95.4) | |
| Multiplicity | 0.184 | ||||
| No | 298 | (64.3) | 113 | (58.5) | |
| Yes | 164 | (35.7) | 80 | (41.5) | |
| Lymphovascular invasion | 0.474 | ||||
| No | 315 | (69.7) | 129 | (66.8) | |
| Yes | 137 | (30.3) | 64 | (33.2) | |
| Preoperative hydronephrosis | 0.089 | ||||
| No | 150 | (32.8) | 77 | (39.7) | |
| Yes | 308 | (67.2) | 117 | (60.3) | |
| History of BC | – | – | 0.379 | ||
| No | 382 | (82.5) | 158 | (81.0) | |
| Previous BC | 22 | (4.8) | 6 | (3.1) | |
| Concurrent BC | 59 | (12.7) | 31 | (15.9) | |
| Pathological stage T | <0.001** | ||||
| pT2 | 195 | (42.3) | 47 | (24.2) | |
| pT3 | 248 | (53.8) | 99 | (51.0) | |
| pT4 | 18 | (3.9) | 48 | (24.7) | |
| Clavien-Dindo classification | 0.683 | ||||
| No | 275 | (60.0) | 118 | (61.8) | |
| Grade I | 61 | (13.3) | 29 | (15.2) | |
| Grade II | 85 | (18.6) | 34 | (17.8) | |
| Grade III | 18 | (3.9) | 4 | (2.1) | |
| Grade IV | 8 | (1.7) | 4 | (2.1) | |
| Grade V | 11 | (2.4) | 2 | (1.0) | |
| Post-OP Complication | |||||
| ESRD | 62 | (13.9) | 19 | (9.9) | 0.170 |
| Ileus | 13 | (2.9) | 4 | (2.1) | 0.556 |
| Follow up (months)c median | 33.5 | 24.2 | 0.049* | ||
a
Chi-Squared test calculated for the difference Variables.
b
Student’s t-test calculated for the difference in means. * < 0.05, ** < 0.01.
c
Wilcoxon rank-sum test calculated for the difference in medians. * < 0.05, ** < 0.01.
UTUC, upper tract urothelial carcinoma; LND, lymph node dissection; BC, bladder cancer; ESRD, end-stage renal disease; NU, nephroureterectomy.