Table 2.
Comparison of histopathological characteristics and molecular patterns of EEC without lymph node involvement (n = 12) and with lymph node involvement (n = 16), Institut Bergonie, 2010–2017.
| Pathological Characteristics | EEC with Negative Lymph Nodes (n = 12) | EEC with Positive Lymph Nodes (n = 16) | |||
|---|---|---|---|---|---|
| n (%) | Mean (SD) | n (%) | Mean (SD) | p-Value 1 | |
| Tumoral size | 46.8 (22.5) | 50.1 (25.9) | 0.7 | ||
| Histological grade | 0.9 | ||||
| Low grade (grade 1 and grade 2) | 3 (25.0) | 5 (31.2) | |||
| High grade (grade 3) | 9 (75.0) | 11 (68.8) | |||
| Myometrial invasion | 0.9 | ||||
| ≤50% | 4 (33.3) | 6 (37.5) | |||
| >50% | 8 (66.7) | 10 (62.5) | |||
| Angioinvasion | 0.013 | ||||
| Absence | 9 (75.0) | 3 (18.8) | |||
| Non-substantial | 1 (8.3) | 4 (25.0) | |||
| Substantial | 2 (16.7) | 9 (56.2) | |||
|
Number of angioinvasion
(if presence of angioinvasion) |
3.9 (9.4) | 7.2 (8.4) | 0.3 | ||
| Stromal Reaction | 0.12 | ||||
| Presence | 5 (41.7) | 12 (75.0) | |||
| Absence | 7 (58.3) | 4 (25.0) | |||
| MELF pattern | 0.07 | ||||
| Presence | 3 (25.0) | 10 (62.5) | |||
| Absence | 9 (75.0) | 6 (37.5) | |||
| Inflammatory infiltration | 0.9 | ||||
| Presence | 5 (41.7) | 6 (37.5) | |||
| Absence | 7 (58.3) | 10 (62.5) | |||
| Peri nervous invasion | 0.4 | ||||
| Presence | 1 (8.3) | 4 (25.0) | |||
| Absence | 11 (91.7) | 12 (75.0) | |||
| Molecular classification group (TCGA) | 0.06 | ||||
| Ultramutated (POLE mutation) | 0 (0.0) | 0 (0.0) | |||
| Hypermutated (MSI) | 4 (33.3) | 9 (56.2) | |||
| Serous-like (TP53 mutation) | 0 (0.0) | 3 (18.8) | |||
| Non specific molecular profile | 8 (66.7) | 4 (25.0) | |||
| CTNNB1 mutation | 0.1 | ||||
| Pathogenic mutation | 5 (41.7) | 2 (12.5) | |||
| No pathogenic mutation | 7 (58.3) | 14 (87.5) | |||
1 Fisher’s exact test; Two Sample t-test.