Table 2.

cEV-associated cell-type specific proteins that were used to assess cell-type specific damage by way of transport.

CD	GN	nTPM, Cell Type *	Functional Annotation Excerpt from uniport.org
CD14	CD14	Mp = 653 Mc = 285	Mediates the innate immune response to bacterial lipopolysaccharide (LPS)
CD40	CD40	Mc = 242 Bc = 148 Ec = 62	Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in Mp and Bc, leading to induction of immunoglobulin secretion
CD41	ITGA2B	Pl Gc = 65 Ec = 2	Part of receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin
CD62P	SELP	Pl Ec = 52 Tc = 9 Gc = 8	Mediates the interaction of activated Ec or Pl with Lc
CD81	CD81	Ec = 345 Mp = 278 Dc = 267 Tc = 137 Bc = 88 Gc = 82	Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains, which act as platforms for receptor clustering and signaling.
CD102	ICAM2	Nk = 114 Ec = 109 Tc = 60 Mp = 57 Bc = 48 Mc = 26	Mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance
CD233	SLC4A1	Ery = 1623	Major integral membrane glycoprotein of the erythrocyte membrane
HSPG2	HSPG2	Ec = 323	Role in vascularization, basement membrane localization

* Normalized mRNA expression levels in single cells (nTPM) as published on the Human Protein Atlas organization website accessed on 26 December 2021 (https://www.proteinatlas.org/) in combination with information from the Human Cell Differentiation Molecules organization (hcdm.org). Bc = B-cells, Dc = dendritic cells, Ec = Endothelial/Epithelial cells, Ery = Erythrocytes, Gc = Granulocytes, Mc = Monocytes, Mp = Macrophages, Nk = natural killer cells, Pl = Platelets, Tc = T-cells.