Table 3.

Potential anti-SARS-CoV-2 drugs and predictive targets identified in this study.

Drug Name	Drug Category	Human Target	In Vitro Activity against SARS-CoV-2
Chloroquine	Quinolines and derivatives	ACE2	EC50  =  1.13 μM [128]
Hydroxychloroquine	Quinolines and derivatives	ACE2	EC50 = 0.72 μM [129]
Alpha-1-proteinase inhibitor	Carboxylic acids and derivatives	TMPRSS2	IC50 = 357 nM (TMPRSS2 inhibitor) [130]
Aluminium	Homogeneous post-transcriptional metal compounds	TMPRSS2	Not tested
Aluminium acetate	Carboxylic acids and derivatives	TMPRSS2	Not tested
Aluminium phosphate	Post-transition metal oxoanionic compounds	TMPRSS2	Not tested
Aprotinin	Carboxylic acids and derivatives	TMPRSS2	IC50 = 0.32–1.65 μM [131]
Cyproterone acetate	Steroids and steroid derivatives	TMPRSS2	Not tested
Filgrastim	Carboxylic acids and derivatives	TMPRSS2	Not tested
Mifepristone	Steroids and steroid derivatives	TMPRSS2	Not tested
Pegfilgrastim	Carboxylic acids and derivatives	TMPRSS2	Not tested